MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

We previously demonstrated that sodium butyrate is neuroprotective in Huntington's disease (HD) mice and that this therapeutic effect is associated with increased expression of mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1/DUSP1). Here we show that enhancing MKP-1 expre...

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Main Authors: Taylor, David M., Moser, Roger, Régulier, Etienne, Breuillaud, Lionel, Dixon, Meredith, Beesen, Ayshe Ana, Elliston, Linda, Silva Santos, Mariana de Fatima, Kim, Jinho, Jones, Lesley, Goldstein, Darlene R., Ferrante, Robert J., Luthi-Carter, Ruth
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711389/
https://ncbi.nlm.nih.gov/pubmed/23392662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4965-11.2013
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