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The Epac1 Signaling Pathway Regulates Cl(−) Secretion via Modulation of Apical KCNN4c Channels in Diarrhea
The apical membrane of intestinal epithelia expresses intermediate conductance K(+) channel (KCNN4), which provides the driving force for Cl(−) secretion. However, its role in diarrhea and regulation by Epac1 is unknown. Previously we have established that Epac1 upon binding of cAMP activates a PKA-...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711306/ https://ncbi.nlm.nih.gov/pubmed/23720748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.467860 |
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