Epac1 mediates protein kinase A–independent mechanism of forskolin-activated intestinal chloride secretion

Intestinal Cl(−) secretion is stimulated by cyclic AMP (cAMP) and intracellular calcium ([Ca(2+)](i)). Recent studies show that protein kinase A (PKA) and the exchange protein directly activated by cAMP (Epac) are downstream targets of cAMP. Therefore, we tested whether both PKA and Epac are involve...

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Detalhes bibliográficos
Main Authors: Hoque, Kazi Mirajul, Woodward, Owen M., van Rossum, Damian B., Zachos, Nicholas C., Chen, Linxi, Leung, George P.H., Guggino, William B., Guggino, Sandra E., Tse, Chung-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806414/
https://ncbi.nlm.nih.gov/pubmed/20038525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200910339
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