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Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets
Heme is a prosthetic group in a large number of essential proteins that have a pivotal role in oxygen transport, storage and electron shuttling. High amounts of free heme are associated with pathological states,. Recently, it has been suggested that activation of Toll-like receptor 4 (TLR4) is one o...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711262/ https://ncbi.nlm.nih.gov/pubmed/20472612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425910369020 |
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