The cationic amphiphile 3,4-bis(tetradecyloxy)benzylamine inhibits LPS signaling by competing with endotoxin for CD14 binding

The identification of the bacterial endotoxin receptors for innate immunity, most notably the Toll-like receptor 4 (TLR4), has sparked great interest in therapeutic manipulation of innate immune system. We have recently developed synthetic molecules that have been shown to inhibit TLR4 activation in...

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Bibliographic Details
Main Authors: Piazza, Matteo, Calabrese, Valentina, Baruffa, Chiara, Gioannini, Theresa, Weiss, Jerrold, Peri, Francesco
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976979/
https://ncbi.nlm.nih.gov/pubmed/20599783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.06.019
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