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Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence
Oncogenic stimuli are thought to induce senescence in normal cells in order to protect against transformation and to induce proliferation in cells with altered p53 and/or retinoblastoma (Rb) pathways. In human fibroblasts, RAS initiates senescence through upregulation of the cyclin-dependent kinase...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC371123/ https://ncbi.nlm.nih.gov/pubmed/15024073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2842-2852.2004 |
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