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Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence

Oncogenic stimuli are thought to induce senescence in normal cells in order to protect against transformation and to induce proliferation in cells with altered p53 and/or retinoblastoma (Rb) pathways. In human fibroblasts, RAS initiates senescence through upregulation of the cyclin-dependent kinase...

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Bibliografske podrobnosti
Main Authors: Benanti, Jennifer A., Galloway, Denise A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC371123/
https://ncbi.nlm.nih.gov/pubmed/15024073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2842-2852.2004
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