Induction of Extracellular Matrix-Remodeling Genes by the Senescence-Associated Protein APA-1

Human fibroblasts undergo cellular senescence after a finite number of divisions, in response to the erosion of telomeres. In addition to being terminally arrested in the cell cycle, senescent fibroblasts express genes that are normally induced upon wounding, including genes that remodel the extrace...

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Detalhes bibliográficos
Main Authors: Benanti, Jennifer A., Williams, Dawnnica K., Robinson, Kristin L., Ozer, Harvey L., Galloway, Denise A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135658/
https://ncbi.nlm.nih.gov/pubmed/12370286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7385-7397.2002
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