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Induction of Extracellular Matrix-Remodeling Genes by the Senescence-Associated Protein APA-1
Human fibroblasts undergo cellular senescence after a finite number of divisions, in response to the erosion of telomeres. In addition to being terminally arrested in the cell cycle, senescent fibroblasts express genes that are normally induced upon wounding, including genes that remodel the extrace...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC135658/ https://ncbi.nlm.nih.gov/pubmed/12370286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7385-7397.2002 |
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