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Cellular Senescence Requires CDK5 Repression of Rac1 Activity
Cellular senescence is a tumor-suppressive process characterized by an irreversible cell cycle exit, a unique morphology, and expression of senescence-associated β-galactosidase (SA-β-Gal). We report here a role for CDK5 in induction of senescent cytoskeletal changes. CDK5 activation is upregulated...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC371103/ https://ncbi.nlm.nih.gov/pubmed/15024070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2808-2819.2004 |
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