Germ Line Transmission of the Cdk4(R24C) Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence

Mutations in CDK4 and its key kinase inhibitor p16(INK4a) have been implicated in the genesis and progression of familial human melanoma. The importance of the CDK4 locus in human cancer first became evident following the identification of a germ line CDK4-Arg24Cys (R24C) mutation, which abolishes t...

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Detalhes bibliográficos
Main Authors: Rane, Sushil G., Cosenza, Stephen C., Mettus, Richard V., Reddy, E. Premkumar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139741/
https://ncbi.nlm.nih.gov/pubmed/11756559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.2.644-656.2002
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