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Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception
The low effectiveness of morphine and related mu opioid analgesics for the treatment of chronic inflammatory pain is a result of opioid-induced release of proinflammatory cytokines and glutamate that lower the pain threshold. In this regard, the use of opioids with metabotropic glutamate-5 receptor...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710855/ https://ncbi.nlm.nih.gov/pubmed/23798416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305461110 |
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