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Use of anion–aromatic interactions to position the general base in the ketosteroid isomerase active site

Although the cation–pi pair, formed between a side chain or substrate cation and the negative electrostatic potential of a pi system on the face of an aromatic ring, has been widely discussed and has been shown to be important in protein structure and protein–ligand interactions, there has been litt...

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Detalhes bibliográficos
Main Authors: Schwans, Jason P., Sunden, Fanny, Lassila, Jonathan K., Gonzalez, Ana, Tsai, Yingssu, Herschlag, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710852/
https://ncbi.nlm.nih.gov/pubmed/23798413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206710110
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