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Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase

A fundamental difference between enzymes and small chemical catalysts is the ability of enzymes to use binding interactions with nonreactive portions of substrates to accelerate chemical reactions. Remote binding interactions can localize substrates to the active site, position substrates relative t...

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Autors principals: Schwans, Jason P., Kraut, Daniel A., Herschlag, Daniel
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732871/
https://ncbi.nlm.nih.gov/pubmed/19706511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901032106
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