Histone deacetylase 10 promotes autophagy-mediated cell survival

Tumor cells activate autophagy in response to chemotherapy-induced DNA damage as a survival program to cope with metabolic stress. Here, we provide in vitro and in vivo evidence that histone deacetylase (HDAC)10 promotes autophagy-mediated survival in neuroblastoma cells. We show that both knockdown...

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Hlavní autoři: Oehme, Ina, Linke, Jan-Peter, Böck, Barbara C., Milde, Till, Lodrini, Marco, Hartenstein, Bettina, Wiegand, Inga, Eckert, Christian, Roth, Wilfried, Kool, Marcel, Kaden, Sylvia, Gröne, Hermann-Josef, Schulte, Johannes H., Lindner, Sven, Hamacher-Brady, Anne, Brady, Nathan R., Deubzer, Hedwig E., Witt, Olaf
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710791/
https://ncbi.nlm.nih.gov/pubmed/23801752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300113110
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