Diacylglycerol kinase alpha is a critical signaling node and novel therapeutic target in glioblastoma and other cancers

While Diacylglycerol kinase alpha (DGKα) has been linked to several signaling pathways related to cancer cell biology, it has been neglected as a target for cancer therapy. The attenuation of DGKα activity via DGKα-targeting siRNA and small-molecule inhibitors, R59022 and R59949, induced caspase-med...

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Détails bibliographiques
Auteurs principaux: Dominguez, Charli L., Floyd, Desiree H., Xiao, Aizhen, Mullins, Garrett R., Kefas, Benjamin A., Xin, Wenjun, Yacur, Melissa N., Abounader, Roger, Lee, Jae K., Wilson, Gabriela Mustata, Harris, Thurl E., Purow, Benjamin W.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710531/
https://ncbi.nlm.nih.gov/pubmed/23558954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0215
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