Diacylglycerol kinase alpha is a critical signaling node and novel therapeutic target in glioblastoma and other cancers

While Diacylglycerol kinase alpha (DGKα) has been linked to several signaling pathways related to cancer cell biology, it has been neglected as a target for cancer therapy. The attenuation of DGKα activity via DGKα-targeting siRNA and small-molecule inhibitors, R59022 and R59949, induced caspase-med...

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Bibliografiska uppgifter
Huvudupphovsmän: Dominguez, Charli L., Floyd, Desiree H., Xiao, Aizhen, Mullins, Garrett R., Kefas, Benjamin A., Xin, Wenjun, Yacur, Melissa N., Abounader, Roger, Lee, Jae K., Wilson, Gabriela Mustata, Harris, Thurl E., Purow, Benjamin W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710531/
https://ncbi.nlm.nih.gov/pubmed/23558954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0215
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