CpG Methylation Changes within the IL2RA Promoter in Type 1 Diabetes of Childhood Onset

None of the polymorphic variants of the IL2RA gene found associated with Type 1 Diabetes (T1D) was shown to have a functional effect. To test if the epigenetic variation could play a role at this locus, we studied the methylation of 6 CpGs located within the proximal promoter of IL2RA gene in 252 T1...

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Detalhes bibliográficos
Main Authors: Belot, Marie-Pierre, Fradin, Delphine, Mai, Nga, Le Fur, Sophie, Zélénika, Diana, Kerr-Conte, Julie, Pattou, François, Lucas, Bruno, Bougnères, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709990/
https://ncbi.nlm.nih.gov/pubmed/23874506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068093
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