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Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes
The insulin (INS) region is the second most important locus associated with Type 1 Diabetes (T1D). The study of the DNA methylation pattern of the 7 CpGs proximal to the TSS in the INS gene promoter revealed that T1D patients have a lower level of methylation of CpG -19, -135 and -234 (p = 2.10(−16)...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3342174/ https://ncbi.nlm.nih.gov/pubmed/22567146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036278 |
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