Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

The insulin (INS) region is the second most important locus associated with Type 1 Diabetes (T1D). The study of the DNA methylation pattern of the 7 CpGs proximal to the TSS in the INS gene promoter revealed that T1D patients have a lower level of methylation of CpG -19, -135 and -234 (p = 2.10(−16)...

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Detalhes bibliográficos
Main Authors: Fradin, Delphine, Le Fur, Sophie, Mille, Clémence, Naoui, Nadia, Groves, Chris, Zelenika, Diana, McCarthy, Mark I., Lathrop, Mark, Bougnères, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342174/
https://ncbi.nlm.nih.gov/pubmed/22567146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036278
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