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Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression

IL2RA, a subunit of the high affinity receptor for interleukin-2 (IL2), plays a crucial role in immune homeostasis. Notably, IL2RA expression is induced in CD4+ T cells in response to various stimuli and is constitutive in regulatory T cells (Tregs). We selected for our study 18 CpGs located within...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Belot, Marie-Pierre, Castell, Anne-Laure, Le Fur, Sophie, Bougnères, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140818/
https://ncbi.nlm.nih.gov/pubmed/30096258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2018.1469893
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