Analysis of Transcriptional Regulation of the Human miR-17-92 Cluster; Evidence for Involvement of Pim-1

The human polycistronic miRNA cluster miR-17-92 is frequently overexpressed in hematopoietic malignancies and cancers. Its transcription is in part controlled by an E2F-regulated host gene promoter. An intronic A/T-rich region directly upstream of the miRNA coding region also contributes to cluster...

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Main Authors: Thomas, Maren, Lange-Grünweller, Kerstin, Hartmann, Dorothee, Golde, Lara, Schlereth, Julia, Streng, Dennis, Aigner, Achim, Grünweller, Arnold, Hartmann, Roland K.
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Diversity Preservation International (MDPI) 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709785/
https://ncbi.nlm.nih.gov/pubmed/23749113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms140612273
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