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L74V increases the reverse transcriptase content of HIV-1 virions with non-nucleoside reverse transcriptase drug-resistant mutations L100I+K103N and K101E+G190S, which results in increased fitness

The fitness of non-nucleoside reverse transcriptase inhibitor (NNRTI) drug-resistant reverse transcriptase (RT) mutants of HIV-1 correlates with the amount of RT in the virions and the RNase H activity of the RT. We wanted to understand the mechanism by which secondary NNRTI-resistance mutations, L1...

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Detalhes bibliográficos
Main Authors: Wang, Jiong, Li, Dongge, Bambara, Robert A., Yang, Hongmei, Dykes, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709637/
https://ncbi.nlm.nih.gov/pubmed/23535575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.050914-0
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