The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys,3) that correlate with reductions in replication efficiency

We evaluated the replication efficiency of the HIV reverse transcriptase (RT) mutants K103N, G190A, and G190S, which confer resistance to the non-nucleoside RT inhibitor efavirenz, using growth competition assays in cell culture. In the absence of efavirenz, the fitness hierarchy was G190S < G190...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Wang, J., Dykes, C., Domaoal, R.A., Koval, C.E., Bambara, R.A., Demeter, L.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484593/
https://ncbi.nlm.nih.gov/pubmed/16504235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.01.014
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