The Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz Stimulates Replication of Human Immunodeficiency Virus Type 1 Harboring Certain Non-nucleoside Resistance Mutations

We measured the effects of non-nucleoside reverse transcriptase (RT) inhibitor-resistant mutations K101E+G190S, on replication fitness and EFV-resistance of HIV(NL4-3). K101E+G190S reduced fitness in the absence of EFV and increased EFV-resistance, compared to either single mutant. Unexpectedly, K10...

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Main Authors: Wang, J., Liang, H., Bacheler, L., Wu, H., Deriziotis, K., Demeter, L.M., Dykes, C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875379/
https://ncbi.nlm.nih.gov/pubmed/20399480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.03.018
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