The pharmacokinetics of methadone in HIV-positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz

AIMS: Methadone is predominantly metabolized by cytochrome P450 3A4 and the non nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz is a recognized inducer of this enzyme. We evaluated the pharmacokinetics of methadone in the presence and absence of efavirenz when administered to HIV infect...

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Detalhes bibliográficos
Main Authors: Clarke, Susan M, Mulcahy, Fiona M, Tjia, John, Reynolds, Helen E, Gibbons, Sara E, Barry, Michael G, Back, David J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015032/
https://ncbi.nlm.nih.gov/pubmed/11298066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.00342.x
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