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Efavirenz Stimulates HIV-1 Reverse Transcriptase RNase H Activity by a Mechanism Involving Increased Substrate Binding and Secondary Cleavage Activity

Efavirenz is a non-nucleoside reverse transcriptase inhibitor used for treating HIV/AIDS. We found that polymerization activity of a reverse transcriptase (RT) with the E478Q mutation that inactivates the RNase H catalytic site is much more sensitive to efavirenz than the wild type RT, indicating th...

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書誌詳細
主要な著者: Muchiri, John M, Li, Dongge, Dykes, Carrie, Bambara, Robert A
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843972/
https://ncbi.nlm.nih.gov/pubmed/23806074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400618q
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