Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase.

We examined the ribonuclease H (RNase H) specificity of human immunodeficiency virus reverse transcriptase (HIV-RT) using heteropolymeric RNAs hybridized to complementary DNAs. Experiments were performed in the presence of excess challenger polymer (poly(rA)-oligo(dT)) to reveal cleavages resulting...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: DeStefano, J J, Mallaber, L M, Fay, P J, Bambara, R A
Format: Artigo
Language:Inglês
Published: Oxford University Press 1993
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310068/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7692401/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.18.4330
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