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Autoreactive Tbet-positive CD4 T Cells Develop Independent of Classic Th1 Cytokine Signaling during EAE

Many autoimmune chronic inflammatory diseases, including multiple sclerosis, are associated with the presence of Th1 and Th17 effector CD4 T cells. Paradoxically, the principal Th1 cytokine IFNγ does not appear necessary for disease, but the key Th1-associated transcription factor Tbet has been repo...

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書目詳細資料
Main Authors: Yeh, Wen-I, McWilliams, Ian L., Harrington, Laurie E.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709433/
https://ncbi.nlm.nih.gov/pubmed/21984703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100031
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