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Autoreactive Tbet-positive CD4 T Cells Develop Independent of Classic Th1 Cytokine Signaling during EAE
Many autoimmune chronic inflammatory diseases, including multiple sclerosis, are associated with the presence of Th1 and Th17 effector CD4 T cells. Paradoxically, the principal Th1 cytokine IFNγ does not appear necessary for disease, but the key Th1-associated transcription factor Tbet has been repo...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3709433/ https://ncbi.nlm.nih.gov/pubmed/21984703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100031 |
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