L-Carnitine Preserves Endothelial Function in a Lamb Model of Increased Pulmonary Blood Flow

BACKGROUND: In our model of congenital heart disease (CHD) with increased pulmonary blood flow (Shunt), we have recently shown a disruption in carnitine homeostasis, associated with mitochondrial dysfunction and decreased eNOS/Hsp90 interactions that contribute to eNOS uncoupling, increased superoxi...

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Autors principals: Sharma, Shruti, Aramburo, Angela, Rafikov, Ruslan, Sun, Xutong, Kumar, Sanjiv, Oishi, Peter E., Datar, Sanjeev A., Raff, Gary, Xoinis, Kon, Kalkan, Gohkan, Fratz, Sohrab, Fineman, Jeffrey R., Black, Stephen M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709010/
https://ncbi.nlm.nih.gov/pubmed/23628882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2013.71
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