Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow

BACKGROUND: Pulmonary vascular function is impaired with increased pulmonary blood flow (PBF). We hypothesized that a peroxisome proliferator-activated receptor-gamma (PPARγ) agonist would mitigate this effect. METHODS: An aorta to pulmonary artery shunt was placed in 11 fetal lambs. Lambs received...

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Hauptverfasser: Oishi, Peter E., Sharma, Shruti, Datar, Sanjeev A., Kumar, Sanjiv, Aggarwal, Saurabh, Lu, Qing, Raff, Gary, Azakie, Anthony, Hsu, Jong-Hau, Sajti, Eniko, Fratz, Sohrab, Black, Stephen M., Fineman, Jeffrey R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977665/
https://ncbi.nlm.nih.gov/pubmed/23128423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2012.149
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