TEZOSENTAN INCREASES NITRIC OXIDE SIGNALING VIA ENHANCED HYDROGEN PEROXIDE GENERATION IN LAMBS WITH SURGICALLY INDUCED ACUTE INCREASES IN PULMONARY BLOOD FLOW

We have previously shown that acute increases in pulmonary blood flow (PBF) are limited by a compensatory increase in pulmonary vascular resistance (PVR) via an endothelin-1 (ET-1) dependent decrease in nitric oxide synthase (NOS) activity. The mechanisms underlying the reduction in NO signaling are...

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Detalhes bibliográficos
Main Authors: Kumar, Sanjiv, Oishi, Peter E., Rafikov, Ruslan, Aggarwal, Saurabh, Hou, Yali, Datar, Sanjeev A., Sharma, Shruti, Azakie, Anthony, Fineman, Jeffrey R., Black, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906673/
https://ncbi.nlm.nih.gov/pubmed/22961736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24383
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