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Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition.

Aspirin inhibits cyclooxygenase, thus preventing thromboxane A2 production in blood platelets and prostacyclin in vascular cells. Aspirin is rapidly hydrolyzed to salicylate in the circulation. The objectives of this study were (a) to evaluate whether administration of salicylate, though ineffective...

詳細記述

保存先:
書誌詳細
主要な著者: Dejana, E, Cerletti, C, de Castellarnau, C, Livio, M, Galletti, F, Latini, R, de Gaetano, G
フォーマット: Artigo
言語:Inglês
出版事項: 1981
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC370901/
https://ncbi.nlm.nih.gov/pubmed/6793630
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