Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition.

Aspirin inhibits cyclooxygenase, thus preventing thromboxane A2 production in blood platelets and prostacyclin in vascular cells. Aspirin is rapidly hydrolyzed to salicylate in the circulation. The objectives of this study were (a) to evaluate whether administration of salicylate, though ineffective...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Dejana, E, Cerletti, C, de Castellarnau, C, Livio, M, Galletti, F, Latini, R, de Gaetano, G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1981
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6793630/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110336
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!