Semi‐Physiological Population Pharmacokinetic Modeling of Oral and Intravenous Paracetamol to Quantify Presystemic Metabolism and Enterohepatic Recirculation

ABSTRACT Paracetamol (PCM) is extensively metabolized in the liver via glucuronidation, sulfation, and oxidation. Although oral and intravenous PCM are commonly used interchangeably, a comprehensive evaluation of PCM metabolism across both routes is lacking. This study aimed to characterize the full...

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Hlavní autoři:	Cedric Lau, Charlotte vanKesteren, Robert M. Smeenk, Marieke M. Beex‐Oosterhuis, Birgit C. P. Koch, Lingtak‐Neander Chan, Yvonne S. Lin, Anne vanRongen, Catherijne A. J. Knibbe, Alwin D. R. Huitema, Hinke Huisman‐Siebinga
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2026-03-01
Edice:	CPT: Pharmacometrics & Systems Pharmacology
Témata:	drug metabolism enterohepatic recirculation paracetamol pharmacometrics presystemic
On-line přístup:	https://doi.org/10.1002/psp4.70168
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