Semi‐Physiological Population Pharmacokinetic Modeling of Oral and Intravenous Paracetamol to Quantify Presystemic Metabolism and Enterohepatic Recirculation

ABSTRACT Paracetamol (PCM) is extensively metabolized in the liver via glucuronidation, sulfation, and oxidation. Although oral and intravenous PCM are commonly used interchangeably, a comprehensive evaluation of PCM metabolism across both routes is lacking. This study aimed to characterize the full...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Cedric Lau, Charlotte vanKesteren, Robert M. Smeenk, Marieke M. Beex‐Oosterhuis, Birgit C. P. Koch, Lingtak‐Neander Chan, Yvonne S. Lin, Anne vanRongen, Catherijne A. J. Knibbe, Alwin D. R. Huitema, Hinke Huisman‐Siebinga
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Wiley 2026-03-01
Cyfres:	CPT: Pharmacometrics & Systems Pharmacology
Pynciau:	drug metabolism enterohepatic recirculation paracetamol pharmacometrics presystemic
Mynediad Ar-lein:	https://doi.org/10.1002/psp4.70168
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!