An Acidic Microenvironment Increases NK Cell Killing of Cryptococcus neoformans and Cryptococcus gattii by Enhancing Perforin Degranulation

Cryptococcus gattii and Cryptococcus neoformans are encapsulated yeasts that can produce a solid tumor-like mass or cryptococcoma. Analogous to malignant tumors, the microenvironment deep within a cryptococcoma is acidic, which presents unique challenges to host defense. Analogous to malignant cells...

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Main Authors: Islam, Anowara, Li, Shu Shun, Oykhman, Paul, Timm-McCann, Martina, Huston, Shaunna M., Stack, Danuta, Xiang, Richard F., Kelly, Margaret M., Mody, Christopher H.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708852/
https://ncbi.nlm.nih.gov/pubmed/23853583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003439
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