Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans

The activity of Rac in leukocytes is essential for immunity. However, its role in NK cell-mediated anti-microbial signaling remains unclear. In this study, we investigated the role of Rac in NK cell mediated anti-cryptococcal killing. We found that Cryptococcus neoformans independently activates bot...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Xiang, Richard F., Stack, Danuta, Huston, Shaunna M., Li, Shu Shun, Ogbomo, Henry, Kyei, Stephen K., Mody, Christopher H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807276/
https://ncbi.nlm.nih.gov/pubmed/26867574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.681544
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