Cryptococcus neoformans Directly Stimulates Perforin Production and Rearms NK Cells for Enhanced Anticryptococcal Microbicidal Activity

NK cells, in addition to possessing antitumor and antiviral activity, exhibit perforin-dependent microbicidal activity against the opportunistic pathogen Cryptococcus neoformans. However, the factors controlling this response, particularly whether the pathogen itself provides an activation or rearmi...

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Detalhes bibliográficos
Main Authors: Marr, Kaleb J., Jones, Gareth J., Zheng, Chunfu, Huston, Shaunna M., Timm-McCann, Martina, Islam, Anowara, Berenger, Byron M., Ma, Ling Ling, Wiseman, Jeremy C. D., Mody, Christopher H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687353/
https://ncbi.nlm.nih.gov/pubmed/19307209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01232-08
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