Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica

BACKGROUND: A family of secreted cathepsin L proteases with differential activities is essential for host colonization and survival in the parasitic flatworm Fasciola hepatica. While the blood feeding adult secretes predominantly FheCL1, an enzyme with a strong preference for Leu at the S(2) pocket...

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Main Authors: Corvo, Ileana, O'Donoghue, Anthony J., Pastro, Lucía, Pi-Denis, Natalia, Eroy-Reveles, Alegra, Roche, Leda, McKerrow, James H., Dalton, John P., Craik, Charles S., Caffrey, Conor R., Tort, José F.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708847/
https://ncbi.nlm.nih.gov/pubmed/23875031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002269
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