Decreased Levels of Proapoptotic Factors and Increased Key Regulators of Mitochondrial Biogenesis Constitute New Potential Beneficial Features of Long-lived Growth Hormone Receptor Gene–Disrupted Mice

Decreased somatotrophic signaling is among the most important mechanisms associated with extended longevity. Mice homozygous for the targeted disruption of the growth hormone (GH) receptor gene (GH receptor knockout; GHRKO) are obese and dwarf, are characterized by a reduced weight and body size, un...

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Bibliographische Detailangaben
Hauptverfasser: Gesing, Adam, Masternak, Michal M., Lewinski, Andrzej, Karbownik-Lewinska, Malgorzata, Kopchick, John J., Bartke, Andrzej
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708518/
https://ncbi.nlm.nih.gov/pubmed/23197187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/gls231
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