Decreased Levels of Proapoptotic Factors and Increased Key Regulators of Mitochondrial Biogenesis Constitute New Potential Beneficial Features of Long-lived Growth Hormone Receptor Gene–Disrupted Mice

Decreased somatotrophic signaling is among the most important mechanisms associated with extended longevity. Mice homozygous for the targeted disruption of the growth hormone (GH) receptor gene (GH receptor knockout; GHRKO) are obese and dwarf, are characterized by a reduced weight and body size, un...

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Detalhes bibliográficos
Main Authors: Gesing, Adam, Masternak, Michal M., Lewinski, Andrzej, Karbownik-Lewinska, Malgorzata, Kopchick, John J., Bartke, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708518/
https://ncbi.nlm.nih.gov/pubmed/23197187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/gls231
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