Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives

The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3))]. Here, we have determined the crystal structu...

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Bibliografiske detaljer
Main Authors: Masuno, Hiroyuki, Ikura, Teikichi, Morizono, Daisuke, Orita, Isamu, Yamada, Sachiko, Shimizu, Masato, Ito, Nobutoshi
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708370/
https://ncbi.nlm.nih.gov/pubmed/23723390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M038307
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