High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28

Src homology 2 (SH2) domains play a critical role in cellular signal transduction. They bind to peptides containing phosphotyrosine (pY) with various specificities that depend on the flanking amino-acid residues. The SH2 domain of growth-factor receptor-bound protein 2 (Grb2) specifically recognizes...

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Detalhes bibliográficos
Main Authors: Higo, Kunitake, Ikura, Teikichi, Oda, Masayuki, Morii, Hisayuki, Takahashi, Jun, Abe, Ryo, Ito, Nobutoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787023/
https://ncbi.nlm.nih.gov/pubmed/24098653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074482
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