Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins

Full activation of T cells and differentiation into effector T cells are essential for many immune responses and require co-stimulatory signaling via the CD28 receptor. Extracellular ligand binding to CD28 recruits protein-tyrosine kinases to its cytoplasmic tail, which contains a YMNM motif. Follow...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Inaba, Satomi, Numoto, Nobutaka, Ogawa, Shuhei, Morii, Hisayuki, Ikura, Teikichi, Abe, Ryo, Ito, Nobutoshi, Oda, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247639/
https://ncbi.nlm.nih.gov/pubmed/27927989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.755173
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