The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR). Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane. Activation of the sterol-sensing nuclear recep...

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Autors principals: Sorrentino, Vincenzo, Nelson, Jessica K., Maspero, Elena, Marques, André R. A., Scheer, Lilith, Polo, Simona, Zelcer, Noam
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2013
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708367/
https://ncbi.nlm.nih.gov/pubmed/23733886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M037713
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