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Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle

SIRT1 is a purported central regulator of skeletal muscle mitochondrial biogenesis. Herein we discuss our recent work utilizing conditional mouse models, which highlight the complexities of SIRT1 biology in vivo, and question its role in regulating mitochondrial function and mitochondrial adaptions...

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Detalhes bibliográficos
Main Authors: Philp, Andrew, Schenk, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707796/
https://ncbi.nlm.nih.gov/pubmed/23792490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JES.0b013e3182956803
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