High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression

Skeletal muscle sirtuin 1 (SIRT1) expression is reduced under insulin-resistant conditions, such as those resulting from high-fat diet (HFD) feeding and obesity. Herein, we investigated whether constitutive activation of SIRT1 in skeletal muscle prevents HFD-induced muscle insulin resistance. To add...

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Main Authors: White, Amanda T., Philp, Andrew, Fridolfsson, Heidi N., Schilling, Jan M., Murphy, Anne N., Hamilton, D. Lee, McCurdy, Carrie E., Patel, Hemal H., Schenk, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216952/
https://ncbi.nlm.nih.gov/pubmed/25159328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00001.2014
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