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p21-Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase-independent Manner
PAK1 plays an important role in proliferation and tumorigenesis, at least partially by promoting ERK phosphorylation of C-RAF (Ser-338) or MEK1 (Ser-298). We observed how that overexpression of a kinase-dead mutant form of PAK1 increased phosphorylation of MEK1/2 (Ser-217/Ser-221) and ERK (Thr-202/T...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707706/ https://ncbi.nlm.nih.gov/pubmed/23653349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426023 |
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