LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr(109) in the p21-binding Domain

The serine/threonine protein kinase LKB1 is a tumor suppressor gene mutated in Peutz-Jeghers syndrome patients. The mutations are found also in several types of sporadic cancer. Although LKB1 is implicated in suppression of cell growth and metastasis, the detailed mechanisms have not yet been elucid...

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Detaylı Bibliyografya
Asıl Yazarlar: Deguchi, Atsuko, Miyoshi, Hiroyuki, Kojima, Yasushi, Okawa, Katsuya, Aoki, Masahiro, Taketo, Makoto M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881753/
https://ncbi.nlm.nih.gov/pubmed/20400510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.079137
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